Is soybean therapy better than ClinOleic for reducing recovery time in cats with permethrin toxicosis?

Shadira Gordon

doi:10.18849/ve.v6i4.469

Abstract

PICO question Is soybean oil-based intravenous lipid emulsion (IVLE) therapy more effective than olive oil-based (ClinOleic IVLE therapy) for reducing time to recovery in cats with permethrin toxicosis?  Clinical bottom line Category of research question Treatment The number and type of study designs reviewed Five case reports and one randomised clinical trial Strength of evidence Weak Outcomes reported Soybean oil-based and ClinOleic IVLE therapies can be used safely as adjuvant treatments to reduce time to recovery in cats with permethrin intoxication. However, the evidence collected suggests that soybean oil-based IVLE therapy is better in reducing the recovery time after permethrin toxicosis as compared to ClinOleic IVLE therapy Conclusion The overall findings showed that the average recovery time after soybean oil-based IVLE therapy across patients with permethrin intoxication was 8.5 hours and the average time to recovery after olive oil-based emulsions (ClinOleic therapy) was 39 hours. This may suggest that soybean oil-based formulations are a better option for reducing the recovery time in cats after permethrin toxicity. Dermal decontamination, supportive care, muscle relaxers, and anticonvulsant drugs are examples of recommended treatments before the administration of any intralipid therapies and must be used based on the clinical signs of each patient  How to apply this evidence in practice The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources. Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care. 

Highlights

A Knowledge Summary by Shadira Gordon DVM MPVM1*Clinical bottom line Category of research question Treatment The number and type of study designs reviewed Five case reports and one randomised clinical trial Strength of evidence Weak Outcomes reported Soybean oil-based and ClinOleic intravenous lipid emulsion (IVLE) therapies can be used safely as adjuvant treatments to reduce time to recovery in cats with permethrin intoxication
All the case reports evaluated in this study suggest that cats with permethrin intoxication had an improvement in clinical signs after the administration of soybean oil-based or olive oil-based intravenous lipid emulsion (IVLE) (ClinOleic) therapies, differences in recovery time were found
In the second case study evaluated (Ceccherini et al, 2015), it was found that four patients had neurological improvement within an average of 5 hours after low-dose soybean oil-based IVLE administration

Summary

A Knowledge Summary by Shadira Gordon DVM MPVM1*

Clinical bottom line Category of research question Treatment The number and type of study designs reviewed Five case reports and one randomised clinical trial Strength of evidence Weak Outcomes reported Soybean oil-based and ClinOleic IVLE therapies can be used safely as adjuvant treatments to reduce time to recovery in cats with permethrin intoxication. The Ceccherini et al (2015) study evaluated four cats between 2–14 years old This case-report showed a mean time to recovery of 5 hours after soybean oil-based IVLE therapy. Kuo et al (2013) evaluated the time to recovery of two cats with permethrin toxicosis treated with soybean oil-based IVLE therapy In this study, both cats showed neurological improvement within an average period of 14 hours. There were no significant differences between control and IVLE treated cats in the hospitalisation times, which can be explained by other factors, such as the availability of owners to collect their cats after recovery

Summary of the evidence

Limitations:

Findings

Methodology Section