Abstract
Objective: Although polymorphisms of adiponectin gene (ADIPOQ) in obesity-related conditions have been the target of research efforts, little is known about this genetic marker in uterine leiomyomas. The aim of this pilot study was to analyze the frequencies of alleles and genotypes of Single Nucleotide Polymorphism ADIPOQ (NM_004797.4):c.214+62G>T (rs1501299) and to correlate it with the risk of uterine fibroids. Study Design: The Test Group comprised 90 women treated surgically for uterine leiomyomas in the Department of Operative Gynecology, Endoscopy and Gynecologic Oncology, Polish Mother’s Memorial Hospital-Research Institute. 90 disease-free individuals were used as Controls. Patients within both groups were additionally stratified into lean, overweight and obese, according to Body Mass Index. Statistical analysis was performed between the two major groups and, furthermore, within the abovementioned subgroups. Results: The study revealed no statistically significant differences in the distribution of alleles and genotypes of SNP ADIPOQ (NM_004797.4):c.214+62G>T (rs1501299) between the two main groups. A weak correlation within distributions of alleles was observed between obese Test Patients and lean Controls. Conclusion: This pilot study has revealed no association between SNP ADIPOQ (NM_004797.4):c.214+62G>T (rs1501299) and uterine fibroids. Further studies on larger groups are warranted to elucidate whether this SNP may be correlated with uterine leiomyomas.
Highlights
Uterine fibroids (UFs), often referred to as uterine leiomyomas, are highly prevalent benign smooth muscle tumors of the uterus
This pilot study has revealed no association between SNP ADIPOQ (NM_004797.4):c.214+62G>T and uterine fibroids
Further studies on larger groups are warranted to elucidate whether this SNP may be correlated with uterine leiomyomas
Summary
Uterine fibroids (UFs), often referred to as uterine leiomyomas, are highly prevalent benign smooth muscle tumors of the uterus. Lifetime risk of this condition varies according to sources, but may reach as high as 75% [1, 2]. Several studies have shown that the prevalence of UF is highest in females aged 26–30 and directly corresponds to overall body adiposity expressed by Body Mass Index (BMI) [4, 5] The latter correlation is consistent with estrogen-dependency doctrine, which has gained particular attention, where excess fatty tissue eventually leads to elevated estrogen levels by facilitating peripheral conversion of androgen to estrogen. The authors have pointed 22 loci which displayed a genome-wide significant susceptibility to leiomyomagenesis These genes were linked with two distinct biological processes: genome stability and genitourinary development. Still little is known about genetic polymorphism in UFs
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