Is room temperature susceptometer really an accurate method to assess hepatocellular iron?

Abstract

We read with interest the study by Mueller et al. describing the use of room temperature susceptometer (RTS) to assess hepatic iron content (HIC).1 This is an interesting clinical application of the methods described by Avrin et al.2,3 This topic is relevant as there is still a need for a cost-effective and efficient iron quantification method in liver disease. However, we think that several points could benefit from clarification and that a more cautious conclusion should be drawn from these results. Overall, as a study of diagnostic accuracy, it would have been beneficial to follow the STARD statement to avoid some pitfalls