Abstract
The compensation on the part of rh-negative mothers who tend to replace their lost (heterozygous) children by having more (recessive) births cannot lead to a stable equilibrium value of rh frequency. The compensation coefficient (t) has been estimated to be roughly 0.36 to 0.40 for American Whites, being much larger than selection intensity (.025 to .10). Although it seems to be on the increase at present, the future direction of change in rh frequency and its ultimate fate in the population is still indefinite, depending upon the future status of selection and compensation.
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