Is Remifentanil Superior to Nitrous Oxide Regarding the Clinical Effects?

Abstract

Is Remifentanil Superior to Nitrous Oxide Regarding the Clinical Effects?Objective: We aimed to compare the effects of NO and remifentanil on hemodynamic parameters, B vitamin values, recovery times, side effects, patient and surgeon satisfactionsMaterial and Methods: Seventy-five ASA I-II women scheduled for abdominal hysterectomy were randomly divided into three groups as nitrous oxide (Group N), remifentanil (Group R) and control (Group K) groups. In each group, the patients were given 2 mg kg propofol, 0.6 mg kg rocuronium during induction of anesthesia. In the remifentanil group following 0.5 μg kg bolus remifentanil, 0.2 μg kg dk infusion was started. Following endotracheal intubation, fresh gas 4 L dk containing 50 % O/N O (in Group N) or medical air (in Group R, K) in with 2 % sevoflurane was given. Hemodynamic parameters, B vitamin, side effects, patient and surgeon satisfactions and recovery times were recorded.Results: In the remifentanil group, intraoperative heart rate (HR) values were found statistically significantly lower than those of the control group at 0., 10., 15., 30. minutes (p Group N > Group K (p<0.05). In Group N, nausea and vomiting were statistically significantly higher than Group R (p=0.001).Conclusion: Although remifentanil provided more rapid recovery with less frequent postoperative nausea, and when compared with nitrous oxide, both of them provided a stable hemodynamic effect and a satisfactory general anesthesia.