Abstract
Aim: The level of antibody production in those vaccinated against coronavirus can be affected by many different situations. There is an important balance between immune response, stress and emotional state. However, it is not known how this situation affects antibody production after vaccination. This study aimed to investigate the correlation between the antibody response induced by the COVID-19 vaccine and the hormones cortisol, a marker of the stress axis, and serotonin, a marker of happiness. 
 Material and Method: Serum cortisol and serotonin levels were analyzed in those who tested positive (n=40) and negative (n=40) for Anti-SARS CoV-2 IgG induced by vaccination. Anti-SARS CoV 2 IgG, cortisol, and serotonin levels were determined by using the ELISA method. The data were compared using the Mann-Whitney U test. The value of p0.05). 
 Conclusion: Consequently, no effect of the stress parameter cortisol and the happiness parameter serotonin, was found in vaccine-induced immunization. It is considered that the different antibody responses in individuals may vary depending on other factors.
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