Abstract
The present study investigated the effect of PGI 2 on ouabain induced arrhythmias in cats. PGI 2 was infused at a dose of 1.0, 2.0 and 5.0 μg/kg·min. PGI 2 in a dose of 1.0 μg/kg·min was without any antiarrhythmic effect. Infusions of 2.0 and 5.0 μg/kg·min PGI 2 in 3 of 10 and 7 of 10 animals, respectively, converted the ouabain induced arrhythmias into a sinus rhythm. The duration of the antiarrhythmic effect after infusion of 2.0 μg/kg·min lasted about 21 min, whereas the higher dose (5.0 μg/kg·min) had a shorter effect (about 2 min). Under these conditions and doses the systolic blood pressure decreased between 35% and 39% and the diastolic blood pressure was reduced by about 50%. Thus PGI 2 showed, when used in the given dose range, an antiarrhythmic effect on ouabain induced arrhythmias in cats. The importance of dosage, methods and species is here discussed.
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