Abstract
BackgroundMean platelet volume (MPV) is a parameter that increases during thrombotic and cardiovascular events. Tamoxifen (Tmx) and aromatase inhibitors (AIs), which are adjuvant endocrine therapies, may cause serious side effects, such as vascular thrombosis. The present study investigated the changes in MPV values of breast cancer patients receiving long-term adjuvant hormone therapy and the relationship of MPV with adverse effects of hormonotherapy.MethodsData of 261 patients who had pathologically confirmed estrogen or progesterone receptor positive invasive breast cancer and had received hormonotherapy for at least a 5-year period were retrospectively analyzed. MPV levels were measured at baseline and at the first and fifth year of hormone therapy.ResultsAll patients were females and their median age was 50 years (range, 27–78 years). The mean MPV value was significantly increased in all patients in the Tmx, AI, and switch groups over time (p<0.001).ConclusionThis is the first study evaluating the relationship between the 5-year adjuvant endocrine therapy and changes in MPV values in breast cancer patients. Monitoring changes in MPV values may be predictive for severe side effects in breast cancer patients receiving hormone therapy.
Highlights
Most breast cancer patients are hormone receptor positive at diagnosis [1]
Mean platelet volume (MPV) levels were measured at baseline and at the first and fifth year of hormone therapy
Data are presented as n (%) or median, where appropriate.Tmx, Tamoxifen; aromatase inhibitors (AIs), Aromatase inhibitor; Switch, Tamoxifen → Aromatase inhibitor; Mixt, Invasive ductal+ Invasive lobular
Summary
Most breast cancer patients are hormone receptor positive at diagnosis [1]. Five to ten years of adjuvant endocrine therapy, such as tamoxifen [Tmx] and aromatase inhibitors [AIs], is recommended for all hormone receptor positive early stage breast cancer patients [2, 3]. Numerous studies have identified the role of platelets in the thrombosis process [8]. Large platelets have higher metabolic and enzymatic activities and are potentially more susceptible to thrombosis [9, 10]. Tamoxifen (Tmx) and aromatase inhibitors (AIs), which are adjuvant endocrine therapies, may cause serious side effects, such as vascular thrombosis. The present study investigated the changes in MPV values of breast cancer patients receiving long-term adjuvant hormone therapy and the relationship of MPV with adverse effects of hormonotherapy
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