Abstract

To assess the risk of postoperative SARS-CoV-2 infection during the COVID-19 pandemic. The CONCEPTION study was a cohort, multidisciplinary study conducted at Conception University Hospital, in France, from March 17th to May 11th, 2020. Our study included all adult patients who underwent minor surgery in one of the seven surgical departments of our hospital: urology, digestive, plastic, gynecological, otolaryngology, gynecology or maxillofacial surgery. Preoperative self-isolation, clinical assessment using a standardized questionnaire, physical examination, nasopharyngeal RT-PCR and chest CT scan performed the day before surgery were part of our active prevention strategy. The main outcome was the occurrence of a SARS-CoV-2 infection within 21 days following surgery. The COVID-19 status of patients after discharge was updated during the postoperative consultation and to ensure the accuracy of data, all patients were contacted again by telephone. A total of 551 patients from six different specialized surgical Departments in our tertiary care center were enrolled in our study. More than 99% (546/551) of included patients underwent a complete preoperative Covid-19 screening including RT-PCR testing and chest CT scan upon admission to the Hospital. All RT-PCR tests were negative and in 12 cases (2.2%), preoperative chest CT scans detected pulmonary lesions consistent with the diagnosis criteria for COVID-19. No scheduled surgery was postponed. One patient (0.2%) developed a SARS-CoV-2 infection 20 days after a renal transplantation. No readmission or COVID-19 -related death within 30 days from surgery was recorded. Minor surgery remained safe in the COVID-19 Era, as long as all appropriate protective measures were implemented. These data could be useful to public Health Authorities in order to improve surgical patient flow during a pandemic.

Highlights

  • From December 2019 onwards, severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) has quickly spread worldwide, leading to a global pandemic, and drastically altering everyday life and clinical practices [1]

  • More than 99% (546/551) of included patients underwent a complete preoperative Covid-19 screening including reverse transcriptase polymerase chain reaction (RT-PCR) testing and chest Computed Tomography (CT) scan

  • Minor surgery remained safe in the COVID-19 Era, as long as all appropriate protective measures were implemented

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Summary

Introduction

From December 2019 onwards, severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) has quickly spread worldwide, leading to a global pandemic, and drastically altering everyday life and clinical practices [1]. In order to offset the higher false negative rate for SARS-CoV-2 RT- PCR, chest Computed Tomography (CT) scan has been proposed as an interesting option for COVID-19 screening and early diagnosis [4, 5]. CT scans have been shown to have a higher sensitivity earlier in the time course of infection than conventional RT-PCR in symptomatic patients. Their utility is still being debated in asymptomatic patients, especially regarding preoperative surgical patients [6]. Peer Review History: PLOS recognizes the benefits of transparency in the peer review process; we enable the publication of all of the content of peer review and author responses alongside final, published articles.

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