Is mifepristone a game changer in induction of labour..?

Abstract

: Induction of labor is defined as artificially stimulating the uterus to start labor. Mifepristone is a synthetic steroid hormone analog that has both anti-progesterone and anti-glucocorticoid activities. This study aimed to study the efficacy of mifepristone in the induction of labor and cervical ripening.: This study was conducted in Gandhi Hospital from August 2022 to November 2022. A total of 100 antenatal cases were admitted for safe confinement after 37 completed weeks and given oral mifepristone 200 mg and assessed for cervical ripening and need for further augmentation and the outcome was studied based on improvement in bishops score assessed after 24 hours of intake of oral mifepristone. It was observed that there was a significant improvement in the bishop’s score 24 hours after giving mifepristone. Out of 100 women who were given mifepristone, 79% delivered vaginally and 21% delivered through emergency cesarean section. The major indication for emergency cesarean section was fetal distress. The majority of patients had good neonatal outcomes and there were no serious maternal complications. Mifepristone is an effective and safe method of induction of labor with significant improvement in Bishop's score within 24 hours of administration.