Abstract
>> boses have been considered as distinct physiopathological concepts through thrombus formation. Arterial thrombi are found in areas of high shear stress and consist mostly of platelets and fibrin. Venous thrombi usually develop in low flow vessels and consist predominantly of erythrocytes and fibrin. Although the data suggest the MPV may potentially be useful as a predictive marker, there are a number of concerns related to the technological limitations and variations in the measurement methods of the MPV that need to be considered. Mean platelet volume does not report a routine part of the complete blood count because of the EDTA induced changes over time. The EDTA-induced platelet shape changes result in a progressive increase in MPV with impedance technology. In general, the MPV increases up to 30% within 5 minutes of exposure and increases further by 10% to 15% over the next 2 hours. 3,4 However, some investigators have reported inconsistent increases in MPV with EDTA storage up to 50%. 3-5 The effect of EDTA on
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