Abstract
Aim: To evaluate the comparison between magnesium sulfate (MgSO4) and placebo for prevention of seizures in mild pre-eclamptic patients. (Clinical trial code: 2016052111020). Methods and material: This double blind randomized clinical trial study was conducted on 500 patients with mild Pre-eclampsia admitted in Arash Hospital in during 2014-2016. The patients entered to equal two groups, 250 patients in group A, received MgSO4 and 250 patients in group Breceived Placebo. Primary outcome was occurrence of convulsion in mild pre-eclamptic patients. Secondary outcomes were 1 and 5 min Apgar scores in infants and number of caesarean section in each group. Results: Mild pre-eclamptic patients in group A did not experience any convulsion; however 3 patients (1.2%) had experienced convulsion in group B. There were no significant differences in convulsion rate (p=0.08), one-min (p=0.43) and five-min Apgar score (p=0.34) between two groups but there was significant differences in numbers of caesarean section, 123 in group A (49.2%) versus 92 in group B (36.8%) between two groups (P=0.005). Conclusion: Our results suggest that the magnesium sulfate and placebo groups are not statistically differ for prevention of seizure.
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