Is lung diffusing capacity lower in expiratory flow limited women compared to non-flow limited women during exercise?

Abstract

Women tend to have smaller lungs than men of the same size as well as narrower airways compared to men when matched for the same lung size. Additionally, women with smaller airways relative to lung size are more likely to experience expiratory flow limitation (EFL) as well as exercise-induced arterial hypoxemia (EIAH). One of the possible causes of EIAH includes excessive widening in the alveolar-to-arterial oxygen pressure difference (A-aDO2) due to diffusion limitation. This study investigated if lung diffusing capacity (D LCO) is lower in women with EFL compared to non-flow limited (NEFL) women during exercise. D LCO was measured using the rebreathing technique at rest and at 40, 60, and 80 % of [Formula: see text] on a treadmill in healthy women with EFL (n = 7; 21.6 ± 2.3) and without EFL (NEFL, n = 9; 21.2 ± 2.3). Arterial oxygen saturation was measured using pulse oximetry (SpO2). There was no difference (p > 0.05) in D LCO between groups at rest or during exercise; however, SpO2 was significantly lower in the EFL females compared to NEFL females during exercise. Due to the lack of differences in D LCO between women with EFL and without EFL, our results suggest that this is not a possible cause for the significant differences in SpO2 between the two groups.