Abstract
BackgroundThe tumor location is the most simple clinical factor and important in liver surgery to make surgical procedure. However, no previous study has investigated the prognostic differences and clinical features of hepatocellular carcinoma showing specific laterality. This study is the first report to focus on the laterality and aimed to lead to more simple and useful predictive factor rather than recent complicated predictive models.MethodsPatients who underwent liver resection for the first time for single tumors located within each lobe between 2000 and 2018 were enrolled. We divided them into two groups based on tumor location: a right-sided group and a left-sided group. Univariable and multivariable analyses were performed to assess survival differences in relation to several other factors.ResultsThere were 595 eligible patients; the 5-year survival rates and disease-free survival rates were 49.5% and 19.1% in the left-sided group and 55.6% and 24.5% in the right-sided group, respectively (p = 0.026). Statistical analyses revealed that the following preoperative prognostic factors were independently significant (p < 0.05) in the left-sided group: indocyanine green retention rate at 15 min, alpha fetoprotein, protein induced by vitamin K absence or antagonists-II level, and larger tumor size.ConclusionThe left-sided group had a poorer prognosis than the right-sided group. A left-sided tumor location is a significant preoperative factor predictive of poor outcome in patients with hepatocellular carcinoma.
Highlights
The tumor location is the most simple clinical factor and important in liver surgery to make surgical procedure
On the basis of this, as the definition showed below, we divided the eligible patients into two groups based on the location of the tumor in the liver: a right-sided group (RSG), whose tumors were located within the right lobe, and a left-sided group (LSG), whose tumors were located within the left lobe
With regard to disease etiology in relation to viral infection, 119 patients were positive for hepatitis B virus (HBV+), 191 were positive for hepatitis C virus (HCV+), 195 were both Hepatitis B virus (HBV)+ and Hepatitis C virus (HCV)+, and 91 had neither HBV+ nor HCV+
Summary
The tumor location is the most simple clinical factor and important in liver surgery to make surgical procedure. No previous study has investigated the prognostic differences and clinical features of hepatocellular carcinoma showing specific laterality. This study is the first report to focus on the laterality and aimed to lead to more simple and useful predictive factor rather than recent complicated predictive models. There have been several types of predictive factors in liver surgery. We explored more simple predictive factors in order to easier project the patient outcomes. This is because it is easy and simple to detect. The tumor location is important in liver surgery to make surgical procedure, no previous.
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