Abstract
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Highlights
Starting from a single cell - the fertilised egg - multicellular organisms undergo repeated rounds of cell division to produce the adult form
We set the cell division intervals to approximate those known from Drosophila development and we modelled the frequency and diversity of mutational outcomes on those observed in the FAST target
We find that dropouts have a major impact on the accuracy of lineage reconstruction (Figure 6B); after 16 cell divisions, the accuracy dropped from 72% to 23%
Summary
Starting from a single cell - the fertilised egg - multicellular organisms undergo repeated rounds of cell division to produce the adult form. Obtaining high resolution (single-cell level) lineages is a challenging task that has been solved only in animals with relatively few cells, such as the nematode Caenorhabditis elegans: its complete lineage (~1000 cells) was deduced by painstaking observation of each cell division under the microscope. This approach is impossible in larger animals, in which most cells are inaccessible to microscopy and their number becomes quickly unmanageable. The bodies of mice and humans consist of 1010 to 1014 cells respectively (Sender et al, 2016)
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