Abstract
BackgroundCurrently, in China, only women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycles can donate oocytes to others, but at least 15 oocytes must be kept for their own treatment. Thus, the aim of this study was to determine whether oocyte donation compromises the cumulative live birth rate (CLBR) of donors and whether it is possible to expand oocyte donors’ crowd.MethodsThis was a retrospective cohort study from August 2015 to July 2017 including a total of 2,144 patients, in which 830 IVF–embryo transfer (IVF-ET) patients were eligible for oocyte donation and 1,314 patients met all other oocyte donation criteria but had fewer oocytes retrieved (10–17 oocytes). All 830 patients were advised to donate approximately three to five oocytes to others and were eventually divided into two groups: the oocyte donation group (those who donated) and the control group (those who declined). The basic patient parameters and CLBR, as well as the number of supernumerary embryos after achieving live birth, were compared. These two factors were also compared in all patients (2,144) with oocyte ≥10.ResultsIn 830 IVF-ET patients who were eligible for oocyte donation, only the oocyte number was significantly different between two groups, and the donation group had more than the control group (25.49 ± 5.76 vs. 22.88 ± 5.11, respectively; p = 0.09). No significant differences were found between the two groups in other factors. The results indicate that the live birth rate in the donation group was higher than that in the control group (81.31% vs. 82.95%, p = 0.371), without significance. In addition, CLBR can still reach as high as 73% when the oocyte number for own use was 10. Supernumerary embryos also increased as the oocyte number increased in all patients (oocyte ≥10).ConclusionsCurrently, oocyte donation did not compromise CLBR, and oocyte donation can decrease the waste of embryos. In addition, in patients with 10 oocytes retrieved, the CLBR was still good (73%). Thus, it is possible to expand oocyte donors if the number of oocyte kept for own use was decreased from 15 to 10 after enough communication with patients.
Highlights
As the social, economic, and environmental factors changed rapidly, the Chinese government implemented two-child policy and even three-child policy in recent years, causing the number of women of advanced maternal age to grow quickly [1,2,3,4]
This study focuses on whether current oocyte donation technology in China reduces the cumulative live birth rate (CLBR) of donors and seeks the possibility of looking for more donors
We hope to be able to make clear how new markers could influence the final results such as follicular fluid anti-Müllerian hormone (AMH) [18], cumulus cells [19], body mass index (BMI), and AMH [20, 21], so as to provide guidance on the number of oocytes donated during egg donation, so that patients can ensure a higher probability of pregnancy and donate enough eggs
Summary
Economic, and environmental factors changed rapidly, the Chinese government implemented two-child policy and even three-child policy in recent years, causing the number of women of advanced maternal age to grow quickly [1,2,3,4]. The available evidence suggests that human fertility declines with advancing age; there is a steady increase in the demand for assisted reproductive treatment among older women [5]. It has been estimated in China that 85%–95% of women who are in need of egg donation cannot receive treatment because they do not have their own gametes. In China, only women undergoing in vitro fertilization/ intracytoplasmic sperm injection (IVF/ICSI) cycles can donate oocytes to others, but at least 15 oocytes must be kept for their own treatment. The aim of this study was to determine whether oocyte donation compromises the cumulative live birth rate (CLBR) of donors and whether it is possible to expand oocyte donors’ crowd
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