Is Helicobacter pylori Infection Associated With Ulcerative Colitis Activity?

Abstract

Objectives: Epidemiological studies have shown an inverse association between <i>Helicobacter pylori</i> infection and ulcerative colitis (UC). In this study, we investigated the protective effects of H. pylori infection on the severity of UC.Methods: This single-center study included 316 patients with newly diagnosed UC based on findings of colonoscopy and upper endoscopy for H. pylori evaluation between January 1994 and December 2015. Patients’ medical records were retrospectively reviewed, and severity of UC was assessed based on endoscopic findings, clinical symptoms, treatment regimens, and Mayo scores.Results: The prevalence of <i>H. pylori</i> infection in patients with UC was 74/316 (23.4%). Based on upper endoscopic findings, the percentage of patients with duodenal ulcers was significantly higher in the H. pylori positive group than that in the <i>H. pylori</i> negative group (27.0% vs. 11.6%, <i>p</i>=0.022). Disease extent and endoscopic severity showed no significant intergroup difference (<i>p</i>=0.765 and <i>p</i>=0.803, respectively). Endoscopic severity was unaffected by the <i>H. pylori</i> infection status, based on the extent of endoscopically documented disease and endoscopic findings. Furthermore, UC-related symptom severity assessed on the basis of stool frequency, rectal bleeding severity, and rate of admission necessitated by UC aggravation was not associated with <i>H. pylori</i> infection (<i>p</i>=0.185, 0.144, and 0.182, respectively). Use of steroids as induction therapy for severe UC did not differ with regard to <i>H. pylori</i> infection (<i>p</i>=0.327). No intergroup difference was observed in disease severity of UC classified using the Mayo score (<i>p</i>=0.323).Conclusions: <i>H. pylori</i> infection was detected in approximately 25.0% of patients with UC. However, the <i>H. pylori</i> infection status was not associated with the severity of UC based on endoscopic disease activity, patients’ symptoms, steroid use, or the Mayo clinic score.