Abstract
Methods Major enrollment criterion was the administration of maraviroc, enfuvirtide, raltegravir, etravirine, darunavir/r or tipranavir/r, alone or in combination, in the latest antiretroviral regimen, decided upon the last genotypic RNA resistance test. This allowed us to assess the genotypic sensitivity score (GSS) at the same time. We also recorded previous presence of specific mutations in all available genotypic resistance tests, their persistence in time and their correlation to the last GSS.
Highlights
Is HAART based on newest active antiretroviral drugs influenced by genotypic sensitivity score (GSS)?MO Ortu*, PV Vitiello, FA Adorni, RR Rossotti, PDV Di Vincenzo, OV Viganò, M Galli and SR Rusconi
R PI: 10FIRVC, 36ILV, 41L, 46IL, 54VLAMTS, 71OVT, 82AFTSLI, 90M and 63P in almost 70–80% of all cases
Undetectable viral load was obtained in 64% of patients without difference between genotypic sensitivity score (GSS) classes (HIV-RNA median value
Summary
MO Ortu*, PV Vitiello, FA Adorni, RR Rossotti, PDV Di Vincenzo, OV Viganò, M Galli and SR Rusconi. Address: University of Milan, Milan, Italy * Corresponding author from Ninth International Congress on Drug Therapy in HIV Infection Glasgow, UK. Published: 10 November 2008 Journal of the International AIDS Society 2008, 11(Suppl 1):P194 doi:10.1186/1758-2652-11-S1-P194. Abstracts of the Ninth International Congress on Drug Therapy in HIV Infection Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1758-2652-11-S1-info.pdf
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