Abstract
RESULTS: Of the 1,944 patients in this cohort, 37% were categorized as obese. Obese patients experienced an SSI rate of 5.6% compared to non-obese patients with an SSI rate of 5.0%. After multivariate analysis, transfusion, laparotomic approach and diabetes remained as statistically significant independent risk factors for SSIs. Obesity was not found to be a statistically significant contributor to SSI in this cohort. However, obesity was associated with risk factors identified in previous research to contribute to SSIs including diabetes, elevated post-operative blood glucose, lower peri-operative oxygenation levels, and longer surgery duration. CONCLUSIONS: This study elucidated possible mechanisms underlying the association between obesity and SSIs in patients undergoing colon surgery. While obesity was not associated with SSIs, it was associated with known risk factors for SSIs. The findings suggest that an infection prevention bundle that prioritizes the laparoscopic approach, minimizes surgery duration and the use of transfusions, and optimizes glucose control and oxygenation, may afford protection from an SSI in the obese individual undergoing colon surgery.
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