Abstract
Evidence-Based Answer Expectant management for at least 2 weeks is a safe and acceptable alternative to medical management of first-trimester pregnancy loss (SOR: A, meta-analyses of RCTs and an observational study). Waiting 6 to 8 weeks may increase successful miscarriage without risk of infection, but may increase the risk of bleeding and need for surgical intervention (SOR: A, metaanalysis of RCTs). Studies beyond 8 weeks are lacking, and therefore a firm endpoint of safety has not been demonstrated.
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