Abstract
Exercise is receiving substantial and increasing attention as a potential treatment for depression. Despite the many positive meta-analytical findings and recommendations of some guidelines to incorporate exercise as a treatment for depression (National Institute for Health and Clinical Excellence, 2009), most clinical trials have significant methodological flaws that limit the generalizability of their findings (Daley, 2008; Rethorst et al., 2009). Furthermore, recent meta-analyses show that, when only robust clinical trials are included, the effects of exercise are “moderate at best” or statistically insignificant (Rimer et al., 2012).
Highlights
Four recent, robust, randomized controlled trials (RCTs) have failed to find any antidepressant effects of exercise: the DEMO (Krogh et al, 2009), DEMO II (Krogh et al, 2012), TReatment with Exercise Augmentation for Depression (TREAD) (Trivedi et al, 2011), and TREAD-UK (Chalder et al, 2012)
The authors concluded that exercise was as effective as placebo and had no biological antidepressant effects
After 8 months, physical activity was shown to be an ineffective and more costly strategy than conventional primary care assistance and resulted in a non-costeffective strategy according to willingnessto-pay thresholds
Summary
Four recent, robust, randomized controlled trials (RCTs) have failed to find any antidepressant effects of exercise: the DEMO (Krogh et al, 2009), DEMO II (Krogh et al, 2012), TReatment with Exercise Augmentation for Depression (TREAD) (Trivedi et al, 2011), and TREAD-UK (Chalder et al, 2012). The DEMO trial (Krogh et al, 2009) compared aerobic exercise, anaerobic exercise, and relaxation (control) groups; after 4 months of intervention, no differences in depressive symptoms, as assessed by the Hamilton scale for depression (HAM-D17) (Hamilton, 1967), were found between the groups. The DEMO II trial (Krogh et al, 2012) compared aerobic exercise and stretching (control) groups; after 3 months, the authors found reductions in HAM-D17 scores in both groups but failed to find differences between the groups.
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