Is Emilin-1 a molecular link contributing to the extension of thoracic aortic aneurysm dissection and increasing the magnitude of the associated hypertension

Simon W Rabkin

doi:10.15761/imm.1000254

Abstract

Is Emilin-1 a molecular link contributing to the extension of thoracic aortic aneurysm dissection and increasing the magnitude of the associated hypertension

Highlights

Patients with acute aortic dissection, the dominant condition in acute aortic syndromes, have a high mortality [1]
Recent data from proteomic analysis of thoracic aortic dissection suggests a new possible molecular mechanism that may lead to increases in both the extent of a TAD and the associated hypertension
Proteomic analysis of aortic tissues from patients with aortic dissection and hypertension found that emilin-1 was down-regulated by approximately 2.3 fold compared to age and sex matched controls [6]

Summary

Introduction

Patients with acute aortic dissection, the dominant condition in acute aortic syndromes, have a high mortality [1]. Refractory hypertension or high blood pressure which is difficult to control or treat, is a major component of acute aortic syndromes. Hypertension is a significant independent predictor of in-hospital mortality in acute aortic syndromes after considering other factors in multivariate analysis [5].

Results

Conclusion