Abstract
Red cell distribution width (RDW) is one of the standard parameters with blood cell counts. Much previous research has indicated that it increases in cases of systemic inflammation or cardiametabolic incident. However, information on the relation of RDW with solid tumors causing systemic inflammation is limited. In the present research, we examined the relation of RDW with malignant and benign lesions of the colon. 115 patients with colon polyps (group 1), and 30 with colon cancer (group 2) who were diagnosed histopathologically in our clinic between January 2010-January 2013 were scanned retrospectively. Patients with anemia, hematologic diseases and active inflammation were excluded. RDW, mean corpuscular volume (MCV), hemoglobin (Hgb) and platelet (Plt) measurements were recorded and their relations with the malignant and benign lesions of the colon were examined. Both groups were similar in age and gender distribution. RDW values of patients with colon cancer were significantly higher than the patients with colon polyp (p=0,01). No significant differences were detected between the two groups in terms of MCV and Plt values (p>0,05). RDW can be used as an early warning biomarker for solid colon tumors. Further prospective research is required on the relations of cheap and easily measured RDW parameters with colon malignancies.
Highlights
Red blood cell distribution width (RDW) is one of the parameters in the standard complete blood count and it reflects the heterogeneity of the sizes of the red blood cells in blood circulation
We examined the relation of Red cell distribution width (RDW) with malignant and benign lesions of the colon
Colorectal cancers have a tendency for haemorrhage more than normal and this reduces iron storages and leads to iron deficiency anaemia
Summary
Red blood cell distribution width (RDW) is one of the parameters in the standard complete blood count and it reflects the heterogeneity of the sizes of the red blood cells in blood circulation. In our study, researched if RDW can be a biomarker which can be used in the early detection of colon cancer. Information on the relation of RDW with solid tumors causing systemic inflammation is limited. We examined the relation of RDW with malignant and benign lesions of the colon. RDW, mean corpuscular volume (MCV), hemoglobin (Hgb) and platelet (Plt) measurements were recorded and their relations with the malignant and benign lesions of the colon were examined. Further prospective research is required on the relations of cheap and measured RDW parameters with colon malignancies
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