Is diabetes a useful diagnostic clue to detect early stage of pancreatic cancer?

Abstract

s / Pancreatology Patients&methods: We recruited 585 patients with cytological or/and pathologically confirmed PDAC in National Taiwan University Hospital from September 2000 to September 2013 and 1716 age-, gender-, and racematched controls who received a screening program in a community located in northern Taiwan. Blood samples were tested for the presence of HCV antibodies (anti-HCV), HBV surface antigen (HBsAg), antibodies against HBsAg (anti-HBs), and HBc (anti-HBc) in all cases and controls. The odds ratios (ORs) of PDAC was estimated by logistic regression analysis with adjustment DM and smoking. Results: HBsAg was positive in 73 cases (12.5%) and 213 controls (12.4%). Anti-HCV was positive in 22 cases (3.8%) and 45 controls (2.6%). Anti-HBs was positive in 338 cases (57.8%) and 1047 controls (61.0%). The estimated ORs of PDAC in multivariate analysis were as follows: diabetes mellitus, 2.08 (95% CI, 1.56-2.76, p<0.001), smoking, 1.36(95% CI, 1.02-1.80, p1⁄40.035), HBsAg+/Anti-HBc+/Anti-HBs-, 0.89 (95% CI, 0.89 to 1.68, p1⁄40.219), HBsAg-/Anti-HBc+/Anti-HBs+, 1.03(95% CI, 0.84 to 1.25, p1⁄40.802). Conclusion: The frequency of HBV and HCV infection was similar in PDAC patients and controls from general population. HBV infection and HCV infection are not associated with risk of PDCA after adjust age, gender, DM and smoking. DM and smoking were independent risk factors of PDAC.