Abstract
Cyclosporine was discovered in 1970, it was isolated from the fungus Tolypocladium inflatum in Switzerland (1). Soon after, an immunosuppressive property was suggested, and by 1978, it was used for the first time in human kidney transplantation to treat organ rejection post-transplant (2). It is now used as a treatment for solid organ, as well as bone marrow transplantation. Its immunomodulatory capacity has extended its use to other immune-mediated diseases such as severe forms of rheumatoid arthritis and psoriasis, steroid-dependent, frequently relapsing or steroid-resistant nephrotic syndrome, graft vs. host disease, refractory posterior uveitis/Behcet disease and amyotrophic lateral sclerosis (2, 3).
Highlights
Cyclosporine was discovered in 1970, it was isolated from the fungus Tolypocladium inflatum in Switzerland [1]
The literature regarding the ototoxic potential of cyclosporine is lacking
Saha et al observed that children with idiopathic nephrotic syndrome were at greater risk for developing hearing loss
Summary
Department of Otolaryngology, Pontificia Universidad Católica de Chile, Santiago, Chile Keywords: cyclosporine, immunosuppressant drug, hearing loss, ototoxicity, dizziness, transplant, nephrotic syndrome Citation: Waissbluth S (2020) Is Cyclosporine Ototoxic? Front. Neurol. 11:593917.
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