Abstract
COVID-19 has often been presented as a hundred diseases of diverse systems and organs needing many specialist experts to study and treat each aspect of this vast scope of pathological complexity in isolation. Alternatively, over the preceding decades, the Merck Manual, numerous publications, and certain patents have described systemic antigen-antibody immune complex diseases caused by viral and other infections with diverse symptoms similar to those of COVID-19. COVID-19 and systemic immune complex disease also selectively impact the same risk groups. Although, immune complex has been identified at sites of COVID-19 pathology in several publications, a recent study reported the unexpected finding that circulating immune complex (CIC) is not elevated in sera or a good biomarker for COVID-19 pathology.
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