Abstract

Severe acute respiratory syndrome COVID-19 targets clinicians primarily to the processes in lung tissue. In other cases, however, clinical evidence reflects the conclusion of endotheliitis development in different parts of vascular bed of SARS-CoV-2 patients. ACE2 dysfunction leads to abnormal activation of renin-angiotensin system and systemic endotheliitis, which is accompanied by abnormal coagulation and sepsis. Sepsis and thrombi formation in various parts of blood vessel bed are of fundamental importance for reasonable choice of preventive and therapeutic tactics in COVID-19. Systemic nature of pathological processes in COVID-19, medical procedures from the first minutes of hospitalization of a patient will be focused on timely diagnosis and therapy of both local and systemic manifestations of COVID-19. There is a difference in the manifestation of risk factors associated with COVID-19 between sexes and age. Many clinicians focus on the fact that severe acute respiratory syndrome COVID-19, called coronavirus SARS-CoV-2, is a systemic disease, which is accompanied by development of pathological processes in lungs and in fact all the organs of human body. The dominant local symptoms of COVID-19 in pulmonary ventilation system in patients at the beginning of pandemic development fix the attention of clinicians on prevention of primarily fatal processes in lung tissue. However, in many cases, it is advisable to immediately after diagnosis establishment begin intensive therapeutic measures aimed at correcting the functions of cardiovascular system, central nervous or digestive systems. Clinical observations accumulating during development of COVID-19 pandemic indicate a variety of systemic pathological events in the body of SARS-CoV-2 patients. Asymptomatic COVID-19 is present also in a currently unknown fraction of the affected patients. Somewhat paradoxically, asymptomatic people had a weaker immune response to SARS-CoV-2 infection. These data formed the basis for development of preventive and therapeutic measures aimed at correction of functions of cardiovascular, immune, endocrine, nervous, digestive, excretory and other functional systems of the body. The older patient (especially smoking) is the more chronic pathological processes are present in his organism (hypertension, ischemic heart disease, asthma and other pathologies). A peculiar pattern of disease is formed in SARS-CoV-2 patients, which reflects both systematicity of the pathology and pronounced individuality of symptoms appearance. Therefore, prophylaxis, therapy and rehabilitation in COVID-19 should be focused on management of systemic pathology including Severe Acute Respiratory Syndrome with respect to local pathological processes and individual features of SARS-CoV-2 patients.

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call