Abstract
The aim of this systematic review is to evaluate the effects of cotoneaster manna on neonatal jaundice. The studies were selected from 1980 to 2017 using the main databases. Eight clinical trials with a total of 862 infants were selected from the 116 primary studies. All these trials had at least two groups for which the studied outcomes were measured before the intervention and at 12, 24, 36 and 48 hours after intervention. Generally, the meta-regression analysis showed a direct insignificant relationship between the baseline bilirubin level in the infants before the intervention and the estimated results. Although the findings confirm the effectiveness of cotoneaster manna products in the treatment of neonatal jaundice compared to the standard interventions or treatments (phototherapy), further clinical trials are strongly recommended, especially with larger sample sizes, more extensive geogra-phical areas, and a variety of subjects in different parts of the world.
Highlights
Neonatal jaundice is one of the most common disorders in the neonatal period that occurs in 60-80% of the healthy babies around the world (Burke et al, 2009)
The primary studies included in this systematic review were randomized or non-randomized clinical trials with or without blinding, in which the subjects were newborns with neonatal jaundice and whose interventions consisted of any product of the manna of cotoneaster plant
All the eligible primary studies were clinical trials; one of them was designed and conducted to examine the effects of the manna of cotoneaster in the prevention of neonatal jaundice, and in another one, the primary outcome evaluated was inconsistent with the primary outcome defined, i.e. serum bilirubin levels in newborns
Summary
Neonatal jaundice is one of the most common disorders in the neonatal period that occurs in 60-80% of the healthy babies around the world (Burke et al, 2009). The serious complication associated with neonatal jaundice is chronic encephalopathy (Muchowski, 2014). Fok conducted a brief review of the Chinese medicine products used in treating neonatal jaundice, and in his overview of the products listed by Dennery, emphasized their long-term use over the centuries. He noted that their effectiveness has not yet been approved in standard clinical trials (Fok, 2001)
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