Abstract
There is a lack of consensus in the current literature regarding how to best manage exposed bone associated with medication-related osteonecrosis of the jaw (MRONJ). A report published in 2014 describes MRONJ as a relapsing and continuously evolving condition and recommends early and aggressive surgical management as the only treatment resulting in consistent mucosal coverage1. Advocates for a more conservative approach argue that the endpoint of treatment is patient comfort and limitation of disease progression. In such cases, antibiotics, oral rinses, and limited bony removal is recommended for stage 1 and stage 2 disease2. The purpose of this study is to answer the following clinical question: In patients diagnosed with stage 1 and stage 2 MRONJ, does conservative treatment result in either clinical improvement or stability of disease over time? We hypothesize that conservative management is associated with either clinical improvement or lack of progression.
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