Is Combined L- and T-Channel Blockade Better Than L-Channel Blockade in Therapy?

Abstract

To the Editor: Ball et al1 elegantly identified functional differences in response to L- and T-Ca channel blockade based on vessel size. The authors suggest that combined L and T calcium channel blockers (CCBs) may have additional therapeutic benefits over conventional L-channel blockers. This hypothesis deserves further investigation. Differential distribution of L- and T-type channels in the glomerular circulation is illustrated by a predominant dilatation of afferent arteriole by nifedipine, …