Abstract
Background Statins are widely used for reducing serum low-density lipoprotein cholesterol (LDL). Fenofibrate, a fibric acid derivative, is used to treat hypertriglyceridemia. Statins are well known to be associated with muscle disorders ranging from simple asymptomatic elevations of creatine phosphokinase (CPK) to rhabdomyolysis. Fibrates are frequently used together with statins when there are significant triglyceride levels along with high LDL levels. The incidence of myopathy associated with statin and fibrate combination is ≈ 0.5–2.5%. We report two cases of significant myopathy apparently precipitated by fenofibrates in patients already taking low doses of a statin.
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