Is coasting effective for preventing ovarian hyperstimulation syndrome in patients receiving a gonadotropin-releasing hormone antagonist during an in vitro fertilization cycle?

Abstract

Objective: To report two cases of coasting during receipt of GnRH antagonists.Design: Case report.Setting: University hospital.Patient(s): One 27-year-old and one 28-year-old woman, both with risk factors for the ovarian hyperstimulation syndrome (OHSS).Intervention(s): Two IVF treatments during which hMG treatment was stopped until E2 decreased to a safer level during receipt of GnRH antagonist.Main Outcome Measure(s): Development of OHSS and pregnancy.Result(s): Embryos were transferred in both women. Neither woman developed OHSS and one ongoing pregnancy was obtained.Conclusion(s): Coasting is feasible when a GnRH antagonist is used during IVF. Further studies are needed to evaluate its preventive role in OHSS.