Abstract
BackgroundIn the present study, we aimed to investigate serum calprotectin levels in patients with diabetic peripheral neuropathy, and possible role of this molecule in the disease pathogenesis.MethodTwenty nine patients with diabetic peripheral neuropathy, 30 type 2 diabetic patients without neuropathy, and 40 healthy controls were enrolled in the study. Fasting plasma glucose (FPG), high-density lipoprotein- cholesterol (HDL-C), low-density lipoprotein- cholesterol (LDL-C), total cholesterol, triglyceride, HbA1c, calprotectin and hsCRP levels were measured in diabetic and healthy control groups.ResultsSerum calprotectin and hsCRP levels were significantly higher in patients with and without neuropathy than healthy controls (p < 0.001, p = 0.017, p < 0.001 and p = 0.001, respectively). Serum calprotectin and hsCRP levels were higher in diabetics with neuropathy than the ones without (p = 0.021 and p < 0.001, respectively). The positive correlation was detected between calprotectin levels and hsCRP and HbA1c in Spearman correlation analysis (r = 0.510, p < 0.001; r = 0.437, p < 0.001 respectively). The results of multiple logistic regression analysis demonstrated the important association between neuropathy development and hsCRP and serum calprotectin levels in diabetic individuals.ConclusionSeum calprotectin levels were increased in diabetic peripheral neuropathy. It may have a role in the pathogenesis of the disease.Electronic supplementary materialThe online version of this article (doi:10.1186/s13098-015-0030-7) contains supplementary material, which is available to authorized users.
Highlights
Diabetes is encountered as one of the most challenging healthcare problems in the 21st century, and its prevalance is higher in developing countries
We aimed to investigate serum calprotectin levels in patients with peripheral neuropathy, and possible role of this molecule in the disease pathogenesis
body mass index (BMI), Fasting plasma glucose (FPG), and HbA1c levels of diabetic patients with and without neuropathy were significantly higher than the controls (p = 0.001, for each)
Summary
Diabetes is encountered as one of the most challenging healthcare problems in the 21st century, and its prevalance is higher in developing countries. The most commonly encountered microvascular complication of type 2 diabetes is diabetic neuropathy with the prevalence of 50-60%. Diabetic peripheral polyneuropathy increases development of foot ulceration risk, and it increases developmental risk of necrosis, which may cause lower. Opinions suggesting that inflammatory processes may play a role in pathogenesis of diabetic polyneuropathy are increasing. It has was shown that peripheral neuropathy was associated with increased levels of proinflammatory immune mediators in patients with type 2 diabetes [4,5]. We aimed to investigate serum calprotectin levels in patients with diabetic peripheral neuropathy, and possible role of this molecule in the disease pathogenesis
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