Abstract

Background: Caffeine is the most commonly consumed pharmacologically active compound in the world. In the neonatal intensive care units (NICU), it is one of the most commonly prescribed drugs to treat Apnea of prematurity. Caffeine, the most commonly used medication in Neonatal Intensive Care Units, has calciuric and osteoclastogenic effects. Our st Aims And Objectives: udy aims to determine the association between duration of therapy of caffeine and metabolic bone disease in less than 34 weeks of gestation . All preterm babies(< 34 weeks) Inclusion Criteria: Exclusion Criteria: Methods: Neonates with major congenital anomalies and congenital bone diseases, babies >34 weeks. To determine the association between the duration of therapy of caffeine and metabolic bone disease, a prospective observational study was conducted including premature neonates less than 34 weeks . Metabolic Bone Disease was evaluated by using Biochemical parameters like calcium ,phosphorous ,ALP, calcium : creatinine ratio at 4 weeks of postnatal period . The Results: prospective observational study included 35 infants. 5.7 % had metabolic bone disease. caffeine therapy showed a association with metabolic bone disease. The duration of therapy of caffeine Conclusion: associated with metabolic bone disease and lesser the gestational age ,requirement of caffeine for longer duration in this group of study and . Future studies are needed to conrm these ndings and determine the lowest dose of caffeine needed to treat effectively apnea of prematurity

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