Is breath-hold time an objective index of exertional dyspnoea in humans?

Abstract

Since dyspnoeic sensation (delta) increases progressively with work rate (WR) and the duration of a volitional breath-hold (tBH) shortens, we wished to explore whether tBH might correlate sufficiently closely with delta to provide a quantitative and descriptor-free index of respiratory sensation during dynamic exercise. Nine healthy males exercised on a cycle ergometer at a series of constant WRs, above and below the lactate threshold. Ventilatory and gas exchange variables were measured breath-by-breath. At each WR, breath-holds to the limit of tolerance were taken; delta was recorded (visual-analog scale) immediately prior to and throughout each breath-hold. During breath-holds, delta increased with time as a "break-away" monoexponential characteristic, reaching the maximum (100%) at the break-point. Despite end-tidal partial pressure of carbon dioxide at the break-point being higher and end-tidal partial pressure of oxygen being lower with increasing WR, the relationship between WR and tBH declined curvilinearly (i.e. with large falls in tBH occurring in the low WR range, but far smaller reductions at higher WRs). The tBH/minute ventilation relationship had a similar form. The relationship between pre-breath-hold delta and tBH was also complex: the large reductions in tBH in the low WR range were associated with only modest increases in pre-BH delta while, at higher WRs, the progressively smaller decrements in tBH were associated with progressively larger increases in delta. We therefore conclude that breath-hold duration is unlikely to provide a useful correlate of exertional dyspnoea during dynamic exercise. Furthermore, the relative prolongation of tBH at high WRs (accounting for the more-extreme levels of end-tidal gas tensions) may reflect the attention-diverting influence of the exercise per se.