Is Bovine Heparin, an Old Fellow, a Safe Anticoagulation Approach during Extracorporeal Circulation Inside the Cardiac Operating Room?

Ivis Levy Fernandes Martins,Christianne Bretas Vieira Scaramello

doi:10.36660/ijcs.20200077

Ivis Levy Fernandes Martins, Christianne Bretas Vieira Scaramello

Open Access

https://doi.org/10.36660/ijcs.20200077

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Abstract

Is Bovine Heparin, an Old Fellow, a Safe Anticoagulation Approach during Extracorporeal Circulation Inside the Cardiac Operating Room?

Highlights

Antithrombotic agents include anticoagulants, antiplatelet and fibrinolytic drugs
unfractionated heparin (UFH) binds with high affinity to antithrombin, increasing its ability to inhibit both factor Xa and thrombin in the coagulation cascade, whilst low-molecular-weight heparins (LMWHs) primarily inhibit factor Xa, and are used therapeutically because of their improved pharmacokinetics and reduced side effects over UFH.[5,6]
Regulatory agencies are currently considering the introduction of bovine UFH for parenteral indications, and ovine heparin is being developed in non-US markets.[6]

Summary

Introduction

Antithrombotic agents include anticoagulants, antiplatelet and fibrinolytic drugs. They are prescribed in several situations related to hemostasis disturbances that favor thrombi formation. Heparin; Blood Coagulation; Extracorporeal Circulation; Cardiac Surgical Prcedures; Patient Safety. Regulatory agencies are currently considering the introduction of bovine UFH for parenteral indications, and ovine heparin is being developed in non-US markets.[6] For this reason, recent studies have discussed the use of bovine UFH in cardiac surgery.[7,8]

Results

Conclusion