Abstract
Background: Isolated limb perfusion (ILP) is a treatment option for malignancies localized to an extremity, and is performed by surgical isolation of the limb which is connected to an extracorporeal circulation system. A high concentration of a chemotherapeutic agent is perfused through the limb, while systemic toxicity is avoided. Currently, the use of packed red blood cells in the priming solution is the norm during ILP. The aim of this study was to investigate the possibility to replace an erythrocyte based prime solution with a crystalloid based prime solution while maintaining the regional metabolic oxygen demand during ILP.
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