Abstract
DOBUTAMINE STRESS echocardiography (DSE) is a useful noninvasive method for detection of functionally relevant cardiac allograft vasculopathy in heart transplant patients (HTXp). It is known, however, that transplant-related ventricular denervation results in up-regulation of -adrenergic receptors and down-regulation of muscarinic receptors. The transplanted, denervated heart may exhibit both larger chronotropic and inotropic responses to circulating cathecholamines. Our aim was to assess whether if the chronotropic responses in HTXp during DSE differ from that of non–heart transplant patients (non-HTXp).
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