Is atrioventricular node ablation combined with His bundle pacing a feasible option for non-controlled atrial arrhythmia? Data from a multicentric registry

Abstract

Ventricular rate control is essential in the management of atrial fibrillation. Atrioventricular node ablation (AVNA) and ventricular pacing can be an effective option when pharmacological rate control is insufficient. However, right ventricular pacing (RVP) induces ventricular desynchronization and increases the risk of heart failure on long term. His bundle pacing (HBP) is a physiological alternative to RVP. Observational studies have demonstrated the feasibility of HBP but there is still very limited data about the feasibility of AVNA after HBP. To evaluate feasibility and safety of HBP followed by AVNA in patients with non-controlled atrial arrhythmia. We included all patients who underwent AVNA for non-controlled atrial arrhythmia after HBP implantation in three hospitals. No back-up right ventricular lead was implanted. AVNA procedures were performed with 8 mm-tip ablation catheter. Acute HBP threshold increase was defined as a threshold elevation > 1 V. HBP thresholds were recorded at 3 months follow-up. AVNA after HBP lead implantation was performed in 36 patients. AVNA was successful in 27 of 36 patients (75%). Modulation of the AV node conduction was obtained in 5. The mean procedure duration was 50 ± 11 min, and fluoroscopy duration was 8 ± 3 min. A mean number of 7.8 ± 3.2 RF applications (430 ± 185 sec) were necessary to obtain an AV block. Acute HBP threshold increase occurred in 7 patients (19.4%) with return to baseline value at day 1 in 5. Mean HBP threshold at implant was 1.39 ± 0.25 V and did not increase at 3 months follow-up (1.29 ± 0.25 V). AV node re-conduction was observed in 5 patients (18.5%) with a second successful ablation procedure in 4. The baseline native QRS duration was 105 ± 8ms and the paced QRS duration was 109 ± 6ms ( Fig. 1 ). AVNA combined with HBP for non-controlled atrial arrhythmia is feasible and does not compromise HBP but seems technically difficult with significant AV nodal re-conduction rate.