Is AMH Really Related to Hyperandrogenism and Insulin Resistance? A Study in Young Women With PCOS

Abstract

Abstract Aims: Polycystic ovary syndrome (PCOS) is an endocrinological disease associated with hyperandrogenism and insulin resistance. Although the place of AMH in polycystic ovary syndrome has been accepted with the recently published guideline, the underlying mechanisms still remain unclear. The aim of this study is to investigate the relationship between hyperandrogenism and AMH using phenotypes A and D in PCOS and to show the place of AMH in the diagnosis of PCOS phenotype without hyperandrogenism. In addition, to reveal the relationship between insulin resistance and AMH. Material and Method: One hundred two patients with PCOS were included in this study. The patients were divided into two groups as Phenotype A and D. In addition, the patients were divided into 2 groups; with (HOMA-IR ≥2.5) and without insulin resistance (IR). The primary outcome was to measure the serum AMH levels between two groups. The secondary outcome was to compare demographic and clinical caracterics (age, BMI, laboratory values). Results: There was no significant difference in AMH values between phenotypes A and D. When patients are divided into 2 groups as PCOS with insulin resistant and without insulin resistant, AMH was found to be significantly lower in the insulin resistant PCOS (p=0.006). The cut-off value for AMH was 6.26 ng/ml, with a sensitivity of 70.4% and a specificity of 62.5%. Conclusion: As a result of our study, we think that the relationship of AMH with hyperandrogenism is not clear and reliable, as it is not a defining indicator between A and D phenotypes in PCOS, but it could be an indicator in determining insülin resistance in PCOS.