Abstract
Anovulation is the major cause of infertility; seen in around 15% of infertile couples and in 40% of women with infertility. Clomiphene citrate has been the gold standard drug for ovulation induction in anovulatory infertility. However, as a singular drug it is not equally effective in all situations. The introduction of an anti-oxidant, N- acetyl cysteine to ovarian stimulation has proven to have many benefits.
Highlights
Infertility has been a growing global public health issue
Clinical pregnancy rate was 94.87% in the combination group which was statistically higher than in CC group (78.94%); p<
N-acetyl cysteine may be a novel adjuvant to clomiphene citrate, more effective than clomiphene citrate alone in inducing and augmenting ovulation. It could be used as an alternative to other insulin sensitizing agents like metformin
Summary
Infertility has been a growing global public health issue. It affects one in every six couples, which is 15% couples in reproductive age group. Clomiphene citrate has been traditionally used as the first line drug in anovulatory infertility. As a singular drug it may not be effective in all cases. Considering the high prevalence of insulin resistance and hyperinsulinemias as the most common etiological factors for resistance to clomiphene as seen in most cases of anovulatory infertility because PCOS contributes about 80% of cases with anovulation. Anovulation is the major cause of infertility; seen in around 15% of infertile couples and in 40% of women with infertility. Clomiphene citrate has been the gold standard drug for ovulation induction in anovulatory infertility. The introduction of an anti-oxidant, N- acetyl cysteine to ovarian stimulation has proven to have many benefits
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