Abstract
To the Editor, The study by Egin and Akar [1] entitled, First observation of MTHFR 678C-A (Ala 222 Ala) single nucleotide polymorphism, in the recent issue of the Journal (2012; 29: 204-5) requires questioning its importance to thrombosis in the light of Dayal et al.’s findings in a mouse model [2]. I used to think that high homocysteine level important in thrombosis, whereas currently I question such knowledge. As such, I think the authors must show the functional effect of their observation in blood coagulation and its relationship to the thermolabile variant of MTHFR ?.
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