Abstract
In the review there are presented the modern scientific concept of the shaping of irritable bowel syndrome (IBS) in children, giver significant etiological aspects of IBS. Genetic and epigenetic, immure and inflammatory, neurological, and psychological factors, chamges im the imtestimal microbiota with emvirommemtal imfluemces were determimed to superimpose manifestations of visceral hypersensitivity and disorders of intestinal motility in the clinical picture of IBS, which in turn depends or a complex interaction between the intestine and the nervous system in the regulation of the digestive system of a growimg orgamism. There has beem formulated the statememt that IBS is a biopsychosocial disorder imvolving disturbances at different levels of the regulation ofpathological mechanisms - from the psycho-social impact to the sensory-motor dysfunction due to a combination of disorders of visceral sensitivity and motor activity of the intestine. New diagnostic methods and means of comprehensive treatment of this common form of the disease in children are described, diagnostic features of IBS in the ambulatory conditions are determined. There are considered various groups of pharmacological agents used in the treatment of IBS, mechanisms of action of artispasmodic drugs of new generations, features of the use ofprebiotics and probiotics, as well as medications for psychosomatic correction.
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