Abstract
29May 2016 THE ROLE OF BIOTECHNOLOGY IN THE AGRICULTURAL DEVELOPMENT IN KSA: A REVIEW Adel E. El-Tarras , Abdulla A. Alharthi and Samer E. Ismail. Biotechnology and Genetic Engineering Research Unit, Deanship of Scientific Research, Taif University, Taif, Saudi Arabia. Cairo University, College of Agriculture, Department of Genetics, Cairo, Egypt.
Highlights
Rupture of aneurysms often present as subarachnoid haemorrhage (SAH)
Revisiting the hypothesis of the possible relationship of estrogen with SAH is utmost necessary to find a rationale therapeutics based on understanding of pathophysiology
Selective estrogen receptors modulators (SERM):Specific estrogen agonists targeted on modulating cerebral vascular ER activity without having any other detrimental effects on other systemic circulation have been recently developed providing a boost to hormone replacement therapy (HRT)
Summary
Rupture of aneurysms often present as subarachnoid haemorrhage (SAH). It is one of the most severe form of strokeReceived: 15 November 2016 Final Accepted: 17 December 2016 Published: January 2017 especially in female population. Cerebral aneurysms are found to occur more commonly in women who achieve early menopause substantiating the role of estrogen as a protective factor against growth of aneurysms[9]. Interestingly estrogen can affect all these factors and thereby increase the risk of cerebral aneurysm formation. Low dose estrogen and hormone replacement therapy promote strengthening of the connective tissue by promoting the formation of collagen 1 and 3 by fibroblasts and thereby preventing aneurysm formation and growth.
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