Abstract
The degree of reversibility in blockade of nodes of Ranvier in frog nerve fibers by tropine- p-tolylacetate (I) or its quaternary methiodide (II) is quite dependent on the extent of N-substitution. The sequence II > I characterizes the relative recoveries in values of nodal excitation parameters following partial blockade at a 5 m m ester incubation level, ester removal and washing. A 1 m m concentration of I added to incubation medium containing 5 m m II reduces by one half the reversibility normally inherent in the nodal blockade by II. Further increments in I level produce no additional reductions in reversibility of blockade in I + II mixtures. These findings are discussed in terms of possible deleterious actions of esters I and II on the lipid sector of excitable membranes.
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