Abstract
SummaryFour to 8 days after ingestion of therapeutic doses of radioiodine (50-200 mc) by patients with metastatic thyroid carcinoma, a rise occurs in blood radioiodine concentration which we attribute to irradiation damage to the thyroid gland or thyroid tumor tissue. This increase we have termed the irradiation produced rise. In a series of patients the magnitude of the IPR in general has been found to increase during radiation thyroidectomy with the quantity of radioiodine retained by the thyroid. In a given patient the magnitude and incidence of the IPR decrease with successive doses as functioning thyroid tissue is progressively destroyed. Finally, when there is no longer any functioning tissue, as demonstrated by absence of I∗ uptake, the blood radioiodine concentration rapidly falls to very low levels and there is no IPR.The blood of 21 patients, in various stages of therapy, was studied. For all of 7 radiation thyroidectomy doses, significant IPR's were found; in thyroidectomized patients with func...
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