Abstract
Meeting abstracts The prognosis of high-grade glioma (HGG) is poor despite advancements in neurosurgery, radio-and chemotherapy. DC-based immunotherapy has emerged as a promising and feasible treatment approach due to its high degree of selectivity and its ability to induce an antigen-specific
Highlights
The prognosis of high-grade glioma (HGG) is poor despite advancements in neurosurgery, radio-and chemotherapy
As irradiation is known to induce oxidation-associated molecular patterns (OAMPs) like oxidized or carbonylated proteins, potent enablers of danger signaling, we hypothesized that irradiation could increase the immunogenicity of FT-treated necrotic tumor cells used to pulse dendritic cells (DCs) vaccines in the context of HGG
Flowcytometric analysis of brain-infiltrating immune cells revealed an increased infiltration of CD3+ T cells and a decreased infiltration of FoxP3+ Tregs, F4/80+ macrophages and Ly6C+ and Ly6G+ myeloid-derived suppressor cells in mice receiving prophylactic DC vaccines pulsed with GL261-FT+IR as compared to mice treated with DCs pulsed with GL261-FT
Summary
Irradiation of necrotic tumor cells used to pulse dendritic cells (DCs) potentiates DC vaccineinduced anti-tumor immunity in a mouse model of high-grade glioma. Lien Vandenberk1*, Abhishek D Garg, Patrizia Agostinis, Tina Verschuere, Carolien Koks, Steven De Vleeschouwer, Stefaan Van Gool. From Society for Immunotherapy of Cancer 29th Annual Meeting National Harbor, MD, USA. From Society for Immunotherapy of Cancer 29th Annual Meeting National Harbor, MD, USA. 6-9 November 2014
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