Abstract
The prognosis of high-grade glioma is poor despite of advanced neurosurgery, radio-and chemotherapy. Dendritic cell (DC)-based immunotherapy has emerged as a promising and feasible treatment approach because of it's high degree of selectivity and the ability to induce a memory response. In our research group we are investigating the efficacy of vaccinating both primary (HGG-2006 trial) and relapsed HGG patients (HGG-IMMUNO-2003 trial) with DC pulsed with autologous whole tumor lysate. Both trials showed a better overall survival compared to historical controls. Currently we are running a placebo-controlled randomized phase IIb clinical trial (HGG-2010) in primary HGG patients.
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