Irradiation by γ-rays reduces the level of H3S10 phosphorylation and weakens the G2 phase-dependent interaction between H3S10 phosphorylation and γH2AX

E Bartova,J Krejci,J Suchankova,S Kozubek,I Raska,R Fedr,Z Zdrahal,S Legartova,G Lochmanova

doi:10.7124/bc.0009eb

Abstract

Irradiation by γ-rays reduces the level of H3S10 phosphorylation and weakens the G2 phase-dependent interaction between H3S10 phosphorylation and γH2AX

Highlights

G., et al.: Human HDAC1 and HDAC2 function in the DNAdamage response to promote DNA nonhomologous endjoining, Nat. Struct
4-Thiazolidinones as privileged heterocycles are in focus since 60th
Main achievements are related to glitazones and set of drug-candidates with antidiabetic, antimicrobial, antiviral and anticancer activities

Summary

Introduction

G., et al.: Human HDAC1 and HDAC2 function in the DNAdamage response to promote DNA nonhomologous endjoining, Nat. Struct. Et al.: Heterochromatin protein 1 is recruited to various types of DNA damage, J. Design and development of new thiazolidinone-based drug-like molecules Danylo Halytsky Lviv National Medical University, Lviv, Ukraine dr_r_lesyk@org.lviv.net 4-Thiazolidinones as privileged heterocycles are in focus since 60th.

Objectives

Results

Conclusion