Abstract
From the histopathologic analysis of some 1000 irradiated mice it was concluded that spontaneouslyoccurring kidney tumors in mice are rare. Irradiation seems to be responsible for producing kidney tumors in mice (proportion 10% of the cases). Radiation-induced kidney tumors are mostly papillary cystadenomas, miliary type.'' The glomerular capsule appears to be most sensitive to the effects of irradiation. Masculinization and a lesser degree of feminization seems to confirm it. While renal tumors in man are considered to originate from the renal tubules, the irradiationinduced tumors in kidneys seem to arise from the glomenalar capsule with secondary involvement of the tubules. Histopathologic changes of the glomeruli from normal to tumor formation are illustrated. (auth)
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